OUR INGREDIENT

Structure of 'Methionyl r-Clostridium

Botulinum Polypeptide-1 Hexapeptide-40'

'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' is developed as recombination of peptide called “MTD” (Macro-molecule Transmission Domain) that has function of skin and target cell permeation and, active protein of botulinum toxin called 'Light Chain'.  'MTD' applied to our ingredient is originated and developed from botulinum toxin 'Heavy Chain', ,which performing a cell-penatration function of botulinum toxin. 

Toxin Complex

(Medical Botox Injection)

Botulinum Light Chain A

Botulinum Heavy Chain

Hemaggultinin

Non-toxin

Non-toxin Non-Hemagglutinin

Composition

Heavy chain : Nerve cell penetration

Light chain : Botulinum Efficacy Part

Hemagglutinin

Non-toxin Non-Hemagglutinin

Commercialization

1980

Example

BOTOX (Allergan, US)

MEDITOXIN (Meditox, Korea)

Not permitted to use in Cosmetic Product

Molcular weight

900KDa

Pure Toxin

(Medical Botox Injection)

Botulinum Light Chain A

Botulinum Heavy Chain

Heavy chain : Nerve cell penetration

Light chain : Botulinum Efficacy Part

1995

XEOMIN (Merz, Germany)

Not permitted to use in Cosmetic Product

150KDa

Our Ingredient

(BPMed_BoLCA_Protein)

Botulinum Light Chain A

MTD Protein

Light Chain + MTD

Botulinum Efficacy Part

Marco-molecule Transmission Domain

(Skin & Nerve cell penetration)

= Recombination of the Protein

2014

BoLCA+ (BPMed cosmetic, Korea)

 

The First Botulinum Ingredient on ICID

BPMed Cosmetic has Exclusivity

50KDa

COMPARISON IF BOTULINUM INGREDIENTS

Platform technology to improve transdermal delivery of 

'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40'

1st Action

2nd Action

Improved penetration of functional materials into stratum corneum and other skin layers by MTD.

Maximized efficacy through the delivery of 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' into specific targets.

Epidermis

Dermis

Subcutaneous Tissue

Muscle Layer

Cell

SKIN AND CELL PENETRATION TECHNOLOGY OF MTD

Cell

Macro-molecule Transmission Domain (MTD)

Botulinum Light Chain

Cell-To-Cell Delivery

Modality of Intracellular delivery of MTD in 'Methionyl

r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40'

Permeate in to cell by MTD technology shows very high Permeability and significantly less cell damage then nano liposome or common peptide ingredients(PTD).

MECHANISM ON NERVE CELL

Normal Neurotransmission Process

01

SNARE Complex Exocitosis 

Acetylcholine Diffusion Binds

to the Receptors on the Muscle

Penetrated in to dermis layer

02

Methionyl r-Clostridium Botulinum 

Polypeptide-1 Hexapeptide-40

Nerve Cell

03

Approaching to the Cell

04

Direct Cell Membrane Translocation

SNAP 25

05

Moves to the SNAP25

06

Cleaves SNAP25 by Light Chain Part

비피메드코스메틱 주식회사 (Head Office)

서울시 강남구 봉은사로 84길 8, 4층 

Tel: 1577-0622 / Fax: 02-565-0622  

E-mail: bpmedcosmetic@bpmedcosmetic.com

© 2020 by BPMed Cosmetic Co., Ltd.